We are pleased to announce funding by The Michael J. Fox Foundation (rapid response innovation award) to investigate a novel quantification paradigm in the imaging of Parkinson’s disease (PD) using dopamine transporter (DAT) SPECT. We hope this work will enable us to detect more subtle changes in sub-regions of the basal ganglia, and to provide novel insights into the relationship between dopaminergic alterations and PD manifestations, while extending the clinical usefulness of this imaging technique.
Three works from our lab were accepted all as oral presentations at the annual SPIE Conference, taking place in San Diego in Feb 2014. We look forward to the conference!
- N. A. Karakatsanis and A. Rahmim
Whole-body PET parametric imaging employing direct 4D nested reconstruction and a generalized non-linear Patlak model
- H. Mohy-ud-Din, N. A. Karakatsanis, M. A. Lodge, J. Tang, and A. Rahmim
Parametric myocardial perfusion PET imaging using physiological clustering
- S. Ashrafinia, N. A. Karakatsanis, H. Mohy-ud-Din, and A. Rahmim
Towards continualized task-based resolution modeling in PET imaging
Position: The Johns Hopkins University School of Medicine, Department of Radiology, Division of Nuclear Medicine is seeking a post-doctoral fellow, to start February 1st, 2014. The research will take place in the Tomographic Image Reconstruction & Analysis Laboratory of Dr. Rahmim, in collaboration with clinical research and imaging experts and an industrial partner, focusing on the development and validation of novel PET imaging techniques for translation into routine clinical imaging. In particular, the post-doctoral fellow will develop innovative oncologic PET/CT image reconstruction, tracer kinetic modeling and tumor quantification algorithms and applications, including simulations and task-based image assessment in the context of dynamic whole-body PET/CT imaging.
Requirements: Qualified candidates will have a Ph.D. in physics, medical physics, biomedical or electrical engineering, or a related field, and established experience in the field of imaging. The candidate should have a strong interest and commitment to research. Creativity with an aim towards independent research is highly emphasized. Prior experience in image reconstruction, algorithm development, simulations and/or kinetic tracer modeling is highly desirable. Knowledge of C programming and familiarity with numerical methods is also preferred.
Application: Interested candidates should send a CV, statement of research interests and the contacts of three references to Dr. Arman Rahmim (email@example.com). Review of applications will begin immediately and continue until the position is filled.
The Johns Hopkins University is an Equal Opportunity Employer.
Five submissions from our lab and our collaborations were accepted to the annual IEEE Medical Imaging Conference, taking place in Seoul this year. The first three (as listed below) were accepted as oral presentations, and the other two as posters. Looking forward to expanding these works and to the simulating discussions:
- N. A. Karakatsanis, Y. Zhou, M. A. Lodge, M. Casey, R. L. Wahl, and A. Rahmim
Quantitative whole-body parametric PET imaging incorporating a generalized Patlak model
- J. Tang, T. Doan, W. Geng, L. Lu, and A. Rahmim
MRI guided myocardial perfusion PET image reconstruction
- A. J. Reader, A. Rahmim, S. H. Keller, S. Blinder, M. Sibomana, and J. -P. Soucy
Multi-Centre assessment of HRRT image uniformity via Ge-68 and F-18 cylindrical and anthropomorphic phantoms
- L. Lu, N. Karakatsanis, , J. Ma, Z. Bian, Y. Han, J. Tang, A. Rahmim, and W. Chen
Performance evaluation of the Inveon PET scanner using GATE based on the NEMA NU-4 Standard
- H. Ghadiri, M. B. Shiran, H. R. Soltanian-Zadeh, A. Rahmim, and M. R. Ay
A fast and hardware mimicking analytic CT simulator
Beyond stop and go: Siemens introduces continuous FlowMotion PET/CT
Looking forward to the always excellent annual meeting of the Society of Nuclear Medicine & Molecular Imaging (SNMMI), held in Vancouver this year (June 8-12, 2013). We will have five presentations from our lab and our collaborations. The abstracts are as follows:
- A. Rahmim and J. Tang
Impact of resolution modeling on detectability: analysis in terms of noise-equivalent quanta
J. Nucl. Med., vol. 54 (suppl. 2): 2119, 2013.
- N. Karakatsanis, M. Lodge, R. Wahl, and A. Rahmim
Direct 4D whole-body PET/CT parametric image reconstruction: concept and comparison vs. indirect parametric imaging
J. Nucl. Med., vol. 54 (suppl. 2): 2133, 2013.
- J. Tang and A. Rahmim
Non-transmural myocardial perfusion defect detection using 5D respiratory and cardiac motion-corrected PET imaging
J. Nucl. Med., vol. 54 (suppl. 2): 488, 2013.
- J. H. O, N. Karakatsanis, A. Rahmim, M. A. Lodge, and R. L. Wahl
A novel imaging method for assessing vessel wall inflammation: dynamic multi-bed PET parametric imaging
J. Nucl. Med., vol. 54 (suppl. 2): 1670, 2013.
- N. George, J. Brasic, L. Oswald, M. Alexander, H. Kuwabara, A. Rahmim, A. Nandi, A. Mathur, R. Rothman, and D. Wong
Differentiation of the neurobiological effects of amphetamine and amphetamine like stimulants
J. Nucl. Med., vol. 54 (suppl. 2): 1737, 2013.
Interesting new development by a very diverse gathering promoting caution against assessment of quality of work purely by the journal impact factor, and warning against its limitations.
“An expert is someone who knows more and more about less and less until he knows absolutely everything about absolutely nothing.”
Nicholas Murray Butler
Our comprehensive review of resolution modeling in PET has been published:
A. Rahmim, J. Qi, and V. Sossi
Resolution modeling in PET imaging: theory, practice, benefits, and pitfalls
Med. Phys., vol. 40, pp. 064301, 2013.
I learnt more in the process of writing this than I could have imagined! It’s already generating very interesting discussions, and we’re in talks with various individuals, including at Siemens, about interesting future directions.
Here we hope you will find useful information about the various things that go on in our lab.